Buffalo Bill is a sativa-dominant cannabis strain bred from Willie’s Wonder and Killer Ken, known for dense, resin-coated buds and a euphoric, uplifting high. Leafly credits New House Seeds as breeder and Doc and Yeti’s in Washington as grower. THC figures range from about 19% to 28%.
Buffalo Bill Strain at a Glance
| Type | Sativa-dominant hybrid |
|---|---|
| Lineage | Willie’s Wonder × Killer Ken |
| Breeder / origin | New House Seeds (grown by Doc and Yeti’s in Washington) |
| THC | 19–28% (typical lab range) |
| CBD | Under 1% |
| Aroma and flavor | sweet, earthy, pine, herbal, citrus, woody |
| Reported effects | euphoric, uplifted, creative, aroused |
| Best for | daytime use, low mood, creative work |
Where Buffalo Bill Comes From
Leafly says Buffalo Bill is a cross of Willy’s Wonder and Killer Ken bred by New House Seeds and grown by Doc and Yeti’s in Washington state. AllBud lists the parents as Williams Wonder and Killer Chem and credits Doc and Yeti Farms. A user review also says Killer Chem, so the second parent’s name may be a mix-up and we flag it as uncertain.
Leafly puts it at about 70% sativa and AllBud at 80%. Leafly lists Wonder Kid as a child strain.
Beyond the breeder credits and the cross, there is little written history. We found no release date or awards, and the Washington grower connection comes from Leafly’s description. If you see Buffalo Bill sold elsewhere, ask for a lab sheet, since THC claims for it range from the high teens to the high 20s.
Buffalo Bill Effects: What It Feels Like
Leafly’s most common reported effects are euphoric, aroused and uplifted, and readers describe a strong onset with a long-lasting, functional high. AllBud describes an uplifting, cerebral high with a sense of peace.
With THC reports ranging this widely, start low.
Buffalo Bill Terpenes, Aroma and Flavor
Leafly describes a sweet, earthy pine aroma and tags pine, earthy and woody. AllBud lists citrus, pine, pineapple, sage and tea. No terpene data was available.
The buds are described as dense with a crystal coating and green and lavender hues.
Side Effects and How to Use Buffalo Bill
Leafly reviewers report dry mouth, dry eyes and dizziness. As with most sativa-leaning, high-THC flower, people who are prone to anxiety or racing thoughts may prefer a small first dose, and anyone new to cannabis should wait a while between puffs before deciding whether to take more.
If you are new to Buffalo Bill, start with one small inhalation or 2.5 mg in an edible and wait before taking more; see our dosing guide.
Do People Use Buffalo Bill for Medical Reasons?
Leafly users cite depression (27%), fatigue and headaches (18% each) from 17 ratings. AllBud lists a long set of possible uses. These are user reports, not medical findings.
These are user reports, not clinical findings. For what research actually supports, see our cannabis health and research section, and talk to your doctor before using cannabis for a health condition.
Strains Like Buffalo Bill
- Jack Herer: classic sativa-leaning hybrid
- Durban Poison: energetic sativa
- Super Lemon Haze: uplifting sativa-leaning
- Pacific OG: Pacific Northwest hybrid
- Willie’s Ghost: shares the Williams Wonder parent
Browse more sativa strains, the full strain directory, or our guide to cannabis strains.
More Sativa Strains to Explore
Burmese Mimosa · Candyland · Canna Country 26 · Blue Skatalite · Blue Dream · Best Friend OG · All sativa strains
Where to Buy Buffalo Bill
Dispensary menus change every week, and Buffalo Bill may be sold under its own name, as a cross or as a pre-roll or vape. The fastest way to find it is to check store menus online before you go. In Chicago, browse Chicago dispensaries and check the menus at stores like BLOC Dispensary Kedzie and Prairie Cannabis – South Loop. In Vancouver, browse Vancouver dispensaries and check the menus at stores like The Herbery NE 78th and Craft Cannabis Andresen. You can also browse licensed dispensaries in every state we cover. Adults 21 and older can buy with a valid photo ID; see cannabis laws by state for purchase limits.
Buffalo Bill FAQ
What is Buffalo Bill a cross of?
Willie’s Wonder and Killer Ken per Leafly. AllBud lists Williams Wonder and Killer Chem.
Who bred Buffalo Bill?
Leafly credits New House Seeds, with Doc and Yeti’s in Washington as grower.
Is Buffalo Bill indica or sativa?
Sativa-dominant, 70% to 80% sativa depending on the source.
How strong is Buffalo Bill?
AllBud lists 25% to 28% THC, but a user lab result showed about 19%.
For adults 21+ in legal states. Strain information reflects breeder descriptions, lab data and user reports; effects vary by person and batch. Not medical advice.
