Mayagüez has 9 dispensaries licensed by the Medical Cannabis Regulatory Board (JRCM). They sell to medical patients only: Puerto Rico patient ID card holders, or visitors with a current medical card from a U.S. state or territory that can be verified, for up to 30 days, plus photo ID. Mayagüez is home to the University of Puerto Rico at Mayagüez (UPRM), with roughly 10,000 students, and it is the second largest store market on the west coast after Aguadilla.
A college town with an age-21 door rule shapes this market. Any student under 21 cannot enter a dispensary at all, even as a patient; a minor patient is served only through a registered authorized companion. For everyone else, the stores line PR-2 as it runs north and south of the city, with a second group in Barrio Guanajibo on the south side and a few in town.
All 9 Licensed Dispensaries in Mayagüez, PR
First Medical Cannabis runs two Mayagüez stores; the other seven are run by seven different companies. Several sit in office buildings or industrial parks rather than retail plazas, so look for the building name in the address.
PR-2 corridor: First Medical Cannabis Mayagüez 1 at kilometer 147.6 in Bo. Sabanetas, Leafwell Mayagüez at kilometer 151.0 in Bo. Algarrobo, and Essence Cannabis Group Mayagüez in the Office Park building at kilometer 156.5. Guanajibo: First Medical Cannabis Mayagüez 2 in the Medical Plaza on Avenida Eugenio María de Hostos, 1511 Mayagüez on Avenida Santa Teresa, and Weedco Mayagüez in the Guanajibo Industrial Park.
In the city: Green West at 74-B Calle Candelaria, Green Doctor on Calle Tenerife in Urb. Sultana, and Weeds in the María L. Arcelay industrial park on Calle José G. Padilla.
How to Choose a Dispensary in Mayagüez
Two stores have public Google ratings, checked October 2026. Weeds has 4.8 stars from about 60 reviews, and First Medical Cannabis Mayagüez 2 has 4.6 from about 90, the most reviewed in town. The other seven have no rating yet. If you are coming from Cabo Rojo or San Germán, the Guanajibo stores are on the south side; from Añasco or Aguadilla, the northern PR-2 stores come first. The sign may carry a brand name, so follow the street address.
Visiting a Dispensary in Mayagüez: Card, ID, Payment and Hours
Bring your Board patient ID card and a photo ID. A registration lasts one year, so renew on time. Visiting patients need their home card, which Puerto Rico recognizes for up to 30 days only if it can be checked in the issuing jurisdiction's database; students from the mainland staying a semester or longer must register under Puerto Rico law. No one under 21 may enter. We have not verified hours, so call ahead and bring cash.
Mayagüez and Puerto Rico Cannabis Laws: Purchase Limits, Public Use and Driving
No dispensary may sell more than one month's supply for a patient, within limits the Board sets. Use is allowed only in private homes and private places where the owner agrees, and at work only if the employer allows it. Campus grounds, plazas, beaches and streets are off limits. Act 42 prohibits smoking cannabis; vaporizing is allowed. Driving under the effects of marijuana or medical cannabis is illegal, and possession without medical authorization is a felony. Our Puerto Rico marijuana laws guide covers the rest.
Cannabis Taxes in Mayagüez
Puerto Rico's sales and use tax (IVU) may apply to your purchase, and your receipt shows any tax charged. We found no extra cannabis tax charged by Mayagüez.
Dispensaries Near Mayagüez
- Dispensaries in Añasco: 3 stores just north.
- Dispensaries in Cabo Rojo: 3 stores to the south.
- Dispensaries in San Germán: 2 stores to the southeast.
- Dispensaries in Rincón: 2 stores up the coast.
- Dispensaries in Aguadilla: 11 stores, the most in the west.
Find every municipio on our Puerto Rico directory, and read Cannabis 101 if you are new.
Mayagüez Dispensary FAQ
Is weed legal in Mayagüez?
Only for registered medical patients. Recreational use is illegal in Puerto Rico.
How many dispensaries are in Mayagüez?
9 licensed medical dispensaries, most of them along PR-2 and in Barrio Guanajibo.
Can UPRM students buy medical cannabis in Mayagüez?
Only registered patients 21 or older can enter a dispensary. Use on campus is not allowed, because patients may use cannabis only in private places.
Can tourists buy weed in Mayagüez?
Only visiting patients with a current, verifiable card from a U.S. state or territory, for up to 30 days.
Can I use a mainland medical card for a full semester?
No. Out-of-state cards are recognized for no more than 30 days; after that you must register as a Puerto Rico patient.
How much can I buy?
No more than one month's supply per sale, within the Board's limits.
Where can I use cannabis in Mayagüez?
Only in private homes and private places with the owner's permission. Smoking is prohibited; vaporizing is allowed.
What time do Mayagüez dispensaries close?
Hours vary and we have not verified them. Call the store.
What is the best dispensary in Mayagüez?
Weeds has 4.8 stars from about 60 Google reviews, and First Medical Cannabis Mayagüez 2 has 4.6 from about 90.
Does your dispensary need more visibility? Cannabis shoppers use The Weed Street Journal to compare stores, read strain guides and check the law before they buy. Advertise with us · Spotted a wrong address, phone number or hours? Tell us and we will fix it free.
How we build this list: Each Mayagüez store appears in the Medical Cannabis Regulatory Board's October 2026 directory of licensed dispensaries. The Board lists company names, so we title stores by company and municipio. Ratings are public Google Maps data where they exist, refreshed monthly.