Sioux Falls has 5 dispensaries licensed by the South Dakota Department of Health. South Dakota is medical-only: you need a South Dakota registry card, as a patient or caregiver, or a confirmed visiting-patient registration with a valid card from your home state. Adults without a card cannot buy. Sioux Falls is the state's largest city, but it has no more stores than Yankton, because in 2021 the city council capped retail dispensary licenses at five.
The five licenses were drawn by lottery in November 2021 from 79 applications, so new stores cannot simply open unless the city changes its ordinance. The four stores with posted hours keep some of the longest schedules in the state, with three open from 8 a.m. to 10 p.m.
All 5 Licensed Dispensaries in Sioux Falls, SD
Every store with a confirmed address is on the south and southwest side of the city, on West 49th Street, South Minnesota Avenue, South Louise Avenue and West Avera Drive.
South Minnesota Avenue and West 49th Street (57105): Genesis Farms Sioux Falls at 3601 S Minnesota Ave and The Flower Shop Sioux Falls at 2211 W 49th St. South Louise Avenue (57106): Royzzz Sioux Falls. West Avera Drive (57108): East River Farms. Address unconfirmed: Canna-Care is on the state's list for Sioux Falls, but we have not confirmed its street address, so call or search before you drive.
Best Sioux Falls Dispensaries for Every Need
Based on public Google ratings and hours, checked October 2026:
- Highest rated: Genesis Farms Sioux Falls (4.9 stars, about 880 reviews), East River Farms (4.9, about 570) and Royzzz Sioux Falls (4.9, about 430), then The Flower Shop (4.8, about 410).
- Most reviewed: Genesis Farms on South Minnesota Avenue.
- Earliest start: Genesis Farms, East River Farms and The Flower Shop open at 8 a.m.; Royzzz at 9.
- Latest close: All four stores with posted hours stay open until 10 p.m.
Visiting a Dispensary in Sioux Falls: Card, ID and Hours
- Two documents: Staff must see a valid registry card or visiting-patient registration and a photo ID issued by a state, a tribe or the federal government, then check the state tracking system.
- Visiting patients: Register with the Department of Health and wait for confirmation before you shop. The same rule covers people who have lived in South Dakota for fewer than 45 days.
Sioux Falls and South Dakota Cannabis Laws: Purchase Limits, Public Use and Driving
A dispensary may sell a patient no more than 3 ounces of cannabis or cannabis products in any 14-day period, and the limit follows you across all five stores.
- Public places: The card does not cover smoking or vaping in a public place, a place open to the public or on public transit. Cardholders under 21 may not smoke or vape at all.
- Driving: Driving under the influence of marijuana is a DUI. There is no THC blood limit, so a charge rests on evidence of impairment.
- Minnesota: The state line is a short drive east, and Minnesota sells to adults 21 and older. Carrying cannabis across the line is a federal crime, and South Dakota can charge a Class 1 misdemeanor for having used a drug when it is detected in your body. See our Minnesota marijuana law guide.
More in our South Dakota marijuana laws guide and state law index.
Cannabis Taxes in Sioux Falls
The Department of Revenue applies the 4.2% state sales tax to medical cannabis, plus municipal tax when you take possession inside city limits. Sioux Falls' municipal rate is 2%, so a Sioux Falls receipt shows 6.2% in sales tax. See our cannabis prices by state page for shelf prices.
Medical Marijuana in Sioux Falls
Get a written certification from a physician, physician assistant or advanced practice registered nurse, then apply to the Department of Health within 90 days. A card costs $75, or $20 for households below 130% of the federal poverty level, and must be renewed every year. Cannabis 101 explains the products.
Dispensaries Near Sioux Falls
- Dispensaries in Tea: 1 store just southwest of the city.
- Dispensaries in Harrisburg: 1 store to the south.
- Dispensaries in Brandon: 1 store to the east.
- Dispensaries in Brookings: 2 stores north on I-29.
- Dispensaries in Mitchell: 3 stores west on I-90.
Browse every town in our South Dakota dispensary directory.
Sioux Falls Dispensary FAQ
Is weed legal in Sioux Falls?
Only medical cannabis for registered patients, caregivers and registered visiting patients. Recreational marijuana is illegal in South Dakota.
How many dispensaries are in Sioux Falls?
5 stores. The city has capped retail dispensary licenses at five since 2021.
Can tourists buy weed in Sioux Falls?
Only visiting medical patients. Register your valid home-state card with the Department of Health and wait for confirmation before you buy.
How much can I buy in Sioux Falls?
No more than 3 ounces of cannabis or cannabis products in any 14-day period, across all stores.
What time do Sioux Falls dispensaries close?
The four stores with posted hours are open until 10 p.m.
Where can I smoke weed in Sioux Falls?
Only in private. Smoking or vaping in public, in places open to the public or on transit is not protected, and use at the dispensary is banned.
Is medical cannabis taxed in Sioux Falls?
Yes, at 6.2%: the 4.2% state sales tax plus the city's 2%.
What is the best dispensary in Sioux Falls?
Genesis Farms, East River Farms and Royzzz all have 4.9 stars from hundreds of reviews. See the ratings list above.
Does your dispensary need more visibility? Cannabis shoppers use The Weed Street Journal to compare stores, read strain guides and check the law before they buy. Advertise with us · Spotted a wrong address, phone number or hours? Tell us and we will fix it free.
How we build this list: Store names and towns come from the South Dakota Department of Health medical cannabis establishments list, and we match each store to its street address in Google Maps. Ratings, review counts and hours come from public Google Maps data. We refresh the list monthly and remove stores that close.